Product ID:SORBITRATE TABLETS
MSDS Date:10/05/1989
FSC:6505
NIIN:01-212-7099
MSDS Number: BXCPS

Emergency Phone: 800-327-8633 MEDICAL

Info Phone: 302-886-3000

Cage: 0A273

Telephone: 302-886-3000

Cage: 0A273

ISOSORBIDE DINITRATE MIXTURE

CAS: 87-33-2

RTECS: LZ4386000

OTHER COMPONENTS (PROPIETARY OR NONHAZARDOUS PER

LD50 LC50 Mixture:LD50 ORAL RAT IS 2000 MG/KG.
Routes of Entry: Inhalation:NO Skin:NO Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ISOSORBIDE DINITRATE CAN BE SLOWLY
ABSORBED THROUGH SKIN, BUT IN TABLET FORM, NO ABSORPTION IS LIKELY
TO OCCUR. RELATIVE TO OTHER MATERIALS, A SINGLE DOSE OF THIS
PRODUCT IS SLIGHTLY TOXIC BY INGESTIO N. TABLETS ARE NOT LIKELY TO
BE INHALED, BUT ANY DUST CAN BE SLOWLY ABSORBED THROUGH MUCOUS
MEMBRANES.
Explanation of Carcinogenicity:NOT CARCINOGENIC.
Effects of Overexposure:ADVERSE EFFECTS FROM SEVERE OVEREXPOSURE CAN
INCLUDE FLUSHING AND PERSPIRING SKIN, VISUAL DISTURBANCE, HEADACHE,
HYPOTENSION, GASTROINTESTINAL DISTRBANCE, CENTRAL NERVOUS SYSTEM
DEPRESSION AND CYANOSI S FOLLOWED BY CONVULSIONS, UNCONSCIOUSNESS,
SLOW BREATHING AND CIRCULATORY COLLAPSE.
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

First Aid:EYES: IMMEDIATELY FLUSH WITH PLENTY OF WATER FOR AT LEAST 15
MINTES. IF SYMPTOMS PERSIST, SEE DOCTOR. SKIN: WASH WITH PLENTY OF
SOAP AND WATER. IF SYMPTOMS PERSIST, SEE DOCTOR. INHALATION: REMOVE
TO F RESH AIR,IF NOT BREATHING, GIVE CPR. IFBREATHING IS DIFFICULT,
GIVE OXYGEN. INGESTION: GIVE 1-2 GLASSES OF WATER. INDUCE VOMIT.
GIVE NOTHING BY MOUTH IF UNCONSCIOUS. SEE DOCTOR.

Extinguishing Media:WATER, CARBON DIOXIDE, MONOAMMONIUM PHOSPHATE DRY
POWDER, HALOGENTAED AGENTS, OR HIGH EXPANSION TYPE FOAMS.
Fire Fighting Procedures:SELF-CONTAINED BREATHING APPARATUS WITH FULL
FACEPIECE AND PROTECTIVE CLOTHING, BARRICADE.
Unusual Fire/Explosion Hazard:CONCENTRATED ISOSORBIDE DINITRATE IS A
POWERFUL EXPLOSIVE. WATER WILL DISSOLVE AWAY OTHER INGREDIENTS AND
CONCENTRATE ISOSORBIDE. THIS IS EXTREMELY HAZARDOUS.

Spill Release Procedures:WEAR SKIN PROTECTION DURING CLEANUP. SWEEP UP
AND RECOVER. WET MATERIAL WITH WATER IN A PLASTIC BAG. WHEN TABLETS
BEGIN TO DISINTEGRATE, DISCARD WITH GENERAL TRASH. WASH RESIDUE
WITH WATER AND FLUSH T O A SEWER SERVICED BY WASTEWATER TREATMENT
FACILTY

Handling and Storage Precautions:AVOID BREATHING DUST. PREVENT SKIN
CONTACT.
Other Precautions:EMPTY CONTAINERS CONTAIN PRODUCT RESIDUE. DO NOT
REUSE EXCEPT FOR STORAGE OR SHIPMENT OF ORIGINAL PRODUCT. REMOVE
ALL PRODUCT RESIDUE AND PUNCTURE OR OTHERWISE DESTROY EMPTY
CONTAINER BEFORE DISPOSAL.

Respiratory Protection:NOT NEEDED WITH ADEQUATE VENTILATION. OTHERWISE,
USE NIOSH/MSHA APPROVED RESPIRATOR IF DUST IS THE ONLY CONCERN.
THERE IS NO AIR PURIFYING RESPIRATOR APPROVED FOR ISOSORBIDE
DINITRATE. ORGANIC CARTRID GES ARE NOT ADEQUATE.
Ventilation:LOCAL EXHAUST.
Protective Gloves:COTTON GLOVES OVER THIN LATEX GLOVES.
Eye Protection:SAFETY GLASSES WITH SIDE SHIELD.
Other Protective Equipment:EYE WASH STATION.
Work Hygienic Practices:HANDS AND FACE SHOULD BE THOROUGHLY WASHED WITH
SOAP AND WATER PRIOR TO EATING, DRINKING OR SMOKING.
Supplemental Safety and Health
NOTE TO PHYSICIAN:SEVERE OVEREXPOSURE CAN LEAD TO METHEMOGLOBIN
FORMATION,WHICH IN SUFFICIENT CONCENTRATION RESULTS IN CLINICAL
CYANOSIS.IF MODERATE,TREAT ONLY BY SUPPORTIVE MEASURES.IF
SEVERE,INTRAVE NOUSLY ADMINISTER 1% METHYLENE BLUE,1-2MG/KG BODY
WEIGHT OVER 5 MINUTES INTERVAL.DO NOT EXCEED 7 MG/KG TOTAL DOSE.

HCC:N1
Melt/Freeze Pt:M.P/F.P Text:158F,70C
Decomp Temp:Decomp Text:NO DATA
Vapor Pres:NO DATA
Vapor Density:NO DATA
Spec Gravity:NO DATA
Solubility in Water:SLIGHT
Appearance and Odor:TABLETS
Percent Volatiles by Volume:NEGL.

Stability Indicator/Materials to Avoid:YES
WATER, ACIDS, ALKALIES, OXIDIZING AGENTS.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:CARBON DIOXIDE, CARBON MONOXIDE,
NITROGEN OXIDES.

Waste Disposal Methods:DISCARDED PRODUCT IS NOT A HAZARDOUS WASTE UNDER
RCRA, 40CFR261. DISPOSE OF IN ACCORDANCE WITH ALL APPLICABLE
FEDERAL, STATE AND LOCAL REGULATIONS

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.